Does Fenofibric Acid Interact with Tacrolimus?
Fenofibric Acid and Tacrolimus have a major drug interaction according to U.S. FDA drug labeling data. Immunosuppressant can produce nephrotoxicity and decreased creatinine clearance, increasing risk of renal function deterioration with fenofibric acid. Monitor renal function and use lowest effective dosage. The mechanism involves nephrotoxicity and decreased renal clearance of fibrate drugs. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Fenofibric Acid Class
- Peroxisome Proliferator Receptor alpha Agonist
- Tacrolimus Class
- Calcineurin Inhibitor Immunosuppressant
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Fenofibric Acid and Tacrolimus occurs because nephrotoxicity and decreased renal clearance of fibrate drugs. Clinically, this means immunosuppressant can produce nephrotoxicity and decreased creatinine clearance, increasing risk of renal function deterioration with fenofibric acid. monitor renal function and use lowest effective dosage. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Fenofibric Acid and your doctor is considering prescribing Tacrolimus (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider