Flecainide + Amiodarone Hydrochloride Interaction
Majorinteraction on record
Description
Class I antiarrhythmic. Amiodarone inhibits flecainide metabolism. Reserve concomitant use; initiate at lower dose and reduce previous dose by 30-50%.
Mechanism
CYP450 inhibition of antiarrhythmic metabolism
Source: NLP:amiodarone hydrochloride