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Does Fluconazole Interact with Azithromycin?

Fluconazole and Azithromycin have a minor drug interaction according to U.S. FDA drug labeling data. No significant pharmacokinetic interaction between fluconazole and azithromycin observed in a three-way crossover study. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Fluconazole Class
Azole Antifungal
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Fluconazole and your doctor is considering prescribing Azithromycin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Fluconazole(Diflucan)+💊 Azithromycin(Zithromax)

Severity & Interaction Details

✅
minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
Azole Antifungal
Drug B class
—
Source
NLP:fluconazole

What this means in plain English

No significant pharmacokinetic interaction between fluconazole and azithromycin observed in a three-way crossover study.

About Fluconazole and Azithromycin

Fluconazole is an Azole Antifungal. You may recognize them by the brand names Diflucan and Zithromax. Fluconazole is given by intravenous (IV) infusion, whereas Azithromycin is taken by mouth. Azithromycin additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.