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Does Fluconazole Interact with Abrocitinib?

Fluconazole and Abrocitinib have a contraindicated drug interaction according to U.S. FDA drug labeling data. Concomitant use increases systemic exposure of abrocitinib and active metabolites due to fluconazole's inhibition of CYP2C19, CYP2C9, and CYP3A4. Avoid concomitant use. The mechanism involves inhibition of cyp2c19 (strong), cyp2c9 (moderate), and cyp3a4 (moderate). Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Fluconazole Class
Azole Antifungal
Abrocitinib Class
Janus Kinase Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Fluconazole and Abrocitinib occurs because inhibition of cyp2c19 (strong), cyp2c9 (moderate), and cyp3a4 (moderate). Clinically, this means concomitant use increases systemic exposure of abrocitinib and active metabolites due to fluconazole's inhibition of cyp2c19, cyp2c9, and cyp3a4. avoid concomitant use. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Fluconazole and your doctor is considering prescribing Abrocitinib (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Fluconazole+💊 Abrocitinib

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Azole Antifungal
Drug B class
Janus Kinase Inhibitor
Source
NLP:fluconazole

What this means in plain English

Concomitant use increases systemic exposure of abrocitinib and active metabolites due to fluconazole's inhibition of CYP2C19, CYP2C9, and CYP3A4. Avoid concomitant use.

What the FDA label says

"Inhibition of CYP2C19 (strong), CYP2C9 (moderate), and CYP3A4 (moderate)"

📖 Source: NLP:fluconazole

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.