Fluvoxamine + Methadone Hydrochloride Interaction
Majorinteraction on record
Description
SSRI and CYP2C19/CYP3A4 inhibitor that increases methadone plasma concentration, resulting in increased opioid effects and risk of fatal overdose.
Mechanism
Inhibition of CYP2C19 and/or CYP3A4-mediated methadone N-demethylation
Source: NLP:methadone hydrochloride