Fluvoxamine + Pomalidomide Interaction

Majorinteraction on record

Description

Strong CYP1A2 inhibitor that increased pomalidomide Cmax by 24% and AUC by 125%, increasing risk of exposure-related toxicities. Avoid concomitant use; if unavoidable, reduce pomalidomide dose.

Mechanism

CYP1A2 inhibition

Source: NLP:pomalidomide