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Does Fosamprenavir Interact with Paroxetine Hydrochloride Hemihydrate?

Fosamprenavir and Paroxetine Hydrochloride Hemihydrate have a unknown drug interaction according to U.S. FDA drug labeling data. Fosamprenavir/Ritonavir Co-administration of fosamprenavir/ritonavir with paroxetine significantly decreased plasma levels of paroxetine. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Unknown
Management
Consult your pharmacist
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Fosamprenavir and your doctor is considering prescribing Paroxetine Hydrochloride Hemihydrate (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Fosamprenavir(Lexiva)+💊 Paroxetine Hydrochloride Hemihydrate(Paroxetine)

Severity & Interaction Details

ℹ️
unknown
Interaction documented — severity unclassified
The FDA label notes an interaction but the severity is not classified in our dataset.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
FDA drug label - paroxetine hydrochloride hemihydrate

What this means in plain English

Fosamprenavir/Ritonavir Co-administration of fosamprenavir/ritonavir with paroxetine significantly decreased plasma levels of paroxetine.

About Fosamprenavir and Paroxetine Hydrochloride Hemihydrate

Fosamprenavir is also sold under the brand name Lexiva. Paroxetine Hydrochloride Hemihydrate is taken by mouth. Paroxetine Hydrochloride Hemihydrate additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.