Paroxetine Hydrochloride Hemihydrate has 34 known drug interactions based on U.S. FDA drug labeling data. Of these, 9 are contraindicated combinations that should be avoided entirely. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Isocarboxazid, Linezolid, Methylene Blue. Patients taking Paroxetine Hydrochloride Hemihydrate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 34
- Contraindicated
- 9
- Major
- 6
- Moderate
- 11
Contraindicated (9)
- Paroxetine Hydrochloride Hemihydrate + Isocarboxazid— Concomitant use increases risk of serotonin syndrome.
- Paroxetine Hydrochloride Hemihydrate + Linezolid— Concomitant use is contraindicated as linezolid is an MAOI with potential for serotonin syndrome.
- Paroxetine Hydrochloride Hemihydrate + Methylene Blue— Concomitant use is contraindicated due to MAOI properties and risk of serotonin syndrome.
- Paroxetine Hydrochloride Hemihydrate + Monoamine Oxidase Inhibitors (Maois)— Concomitant use is contraindicated due to risk of serotonin syndrome.
- Paroxetine Hydrochloride Hemihydrate + Phenelzine— Concomitant use increases risk of serotonin syndrome.
- Paroxetine Hydrochloride Hemihydrate + Pimozide— Paroxetine increases pimozide AUC by 151% and Cmax by 62%, leading to increased QT prolongation risk. Contraindicated du…
- Paroxetine Hydrochloride Hemihydrate + Selegiline— Concomitant use increases risk of serotonin syndrome.
- Paroxetine Hydrochloride Hemihydrate + Thioridazine— Concomitant use is contraindicated; see contraindications and warnings sections.
- Paroxetine Hydrochloride Hemihydrate + Tranylcypromine— Concomitant use increases risk of serotonin syndrome.
Major (6)
- Paroxetine Hydrochloride Hemihydrate + Acetylsalicylic Acid— Increased risk of bleeding with concurrent use; inform patients of increased bleeding risk.
- Paroxetine Hydrochloride Hemihydrate + Clopidogrel— Increased risk of bleeding with concurrent use; inform patients of increased bleeding risk.
- Paroxetine Hydrochloride Hemihydrate + Heparin— Increased risk of bleeding with concurrent anticoagulant use; inform patients of increased bleeding risk.
- Paroxetine Hydrochloride Hemihydrate + Tamoxifen— Consider alternative antidepressant with little or no CYP2D6 inhibition due to paroxetine's effect on tamoxifen metaboli…
- Paroxetine Hydrochloride Hemihydrate + Tryptophan— Concomitant use may cause serotonin syndrome with adverse effects including headache, nausea, sweating, and dizziness. C…
- Paroxetine Hydrochloride Hemihydrate + Warfarin— Monitor for adverse reactions and reduce dosage as warranted. Increased risk of bleeding when used with anticoagulants.
Moderate (11)
- Paroxetine Hydrochloride Hemihydrate + Amphetamine— Caution advised due to potential for serotonin syndrome when coadministered with paroxetine.
- Paroxetine Hydrochloride Hemihydrate + Atomoxetine— Paroxetine inhibits CYP2D6 metabolism of atomoxetine, potentially increasing atomoxetine levels.
- Paroxetine Hydrochloride Hemihydrate + Buspirone— Concomitant use increases risk of serotonin syndrome. Monitor patients during treatment initiation and dosage increases.
- Paroxetine Hydrochloride Hemihydrate + Cimetidine— Cimetidine inhibits cytochrome P450 enzymes, potentially affecting paroxetine metabolism and pharmacokinetics.
- Paroxetine Hydrochloride Hemihydrate + Desipramine— Paroxetine inhibits CYP2D6 metabolism of desipramine, potentially increasing desipramine levels.
- Paroxetine Hydrochloride Hemihydrate + Fentanyl— Caution advised due to potential for serotonin syndrome when coadministered with paroxetine.
- Paroxetine Hydrochloride Hemihydrate + Lithium— Caution advised due to potential for serotonin syndrome when coadministered with paroxetine.
- Paroxetine Hydrochloride Hemihydrate + Risperidone— Paroxetine inhibits CYP2D6 metabolism of risperidone, potentially increasing risperidone levels.
- Paroxetine Hydrochloride Hemihydrate + St. John'S Wort— Caution advised due to potential for serotonin syndrome when coadministered with paroxetine.
- Paroxetine Hydrochloride Hemihydrate + Tramadol— Caution advised due to potential for serotonin syndrome when coadministered with paroxetine.
- Paroxetine Hydrochloride Hemihydrate + Triptans— Rare postmarketing reports of serotonin syndrome. Careful observation advised if concomitant use is clinically warranted…