Does Fosamprenavir Calcium Interact with Rosuvastatin?
Fosamprenavir Calcium and Rosuvastatin have a unknown drug interaction according to U.S. FDA drug labeling data. 700 mg twice daily plus ritonavir 100 mg twice daily for 2 weeks 15 ↓14 (↓28 to ↑4) ↔ ↑28 (↑12 to ↑46) (25-O-desacetylrifabutin metabolite) ↑579 (↑479 to ↑698) ↑1,120 (↑965 to ↑1,300) ↑2,510 (↑1,910 to ↑3,300) Rifabutin + 25-O-desacetylrifabutin metabolite NA ↑64 (↑46 to ↑84) NA Rosuvastatin 10-mg single dose 700 mg twice daily plus ritonavir 100 mg twice daily for 7 days ↑45 ↑8 NA Table 13. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Rosuvastatin Class
- HMG-CoA Reductase Inhibitor
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Fosamprenavir Calcium and your doctor is considering prescribing Rosuvastatin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider