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Does Ganciclovir Interact with Flucytosine?

Ganciclovir and Flucytosine have a moderate drug interaction according to U.S. FDA drug labeling data. Associated with myelosuppression or nephrotoxicity. Coadministration considered only if benefits outweigh risks. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Flucytosine Class
Nucleoside Analog Antifungal
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Ganciclovir and your doctor is considering prescribing Flucytosine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Ganciclovir(Zirgan)+💊 Flucytosine(Ancobon)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Nucleoside Analog Antifungal
Source
NLP:ganciclovir

What this means in plain English

Associated with myelosuppression or nephrotoxicity. Coadministration considered only if benefits outweigh risks.

About Ganciclovir and Flucytosine

Flucytosine is a Nucleoside Analog Antifungal. You may recognize them by the brand names Zirgan and Ancobon. Ganciclovir is given by intravenous (IV) infusion, whereas Flucytosine is taken by mouth. Both Ganciclovir and Flucytosine carry an FDA boxed warning — the agency's most serious safety designation.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.