Does Gemfibrozil Interact with Alogliptin And Pioglitazone?
Gemfibrozil and Alogliptin And Pioglitazone have a major drug interaction according to U.S. FDA drug labeling data. Strong CYP2C8 inhibitor significantly increases pioglitazone exposure and half-life. Maximum recommended dose limited to 25 mg alogliptin and 15 mg pioglitazone daily. The mechanism involves cyp2c8 inhibition increases pioglitazone auc and half-life. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Gemfibrozil Class
- Peroxisome Proliferator Receptor alpha Agonist
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Gemfibrozil and Alogliptin And Pioglitazone occurs because cyp2c8 inhibition increases pioglitazone auc and half-life. Clinically, this means strong cyp2c8 inhibitor significantly increases pioglitazone exposure and half-life. maximum recommended dose limited to 25 mg alogliptin and 15 mg pioglitazone daily. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Gemfibrozil and your doctor is considering prescribing Alogliptin And Pioglitazone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider