Does Glasdegib Interact with Cyp3a Inducers?
Glasdegib and Cyp3a Inducers have a major drug interaction according to U.S. FDA drug labeling data. Co-administration decreases glasdegib plasma concentrations, potentially reducing efficacy. Avoid concomitant use. The mechanism involves cyp3a induction decreases glasdegib plasma concentrations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Glasdegib Class
- Hedgehog Pathway Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Glasdegib and Cyp3a Inducers occurs because cyp3a induction decreases glasdegib plasma concentrations. Clinically, this means co-administration decreases glasdegib plasma concentrations, potentially reducing efficacy. avoid concomitant use. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Glasdegib and your doctor is considering prescribing Cyp3a Inducers (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider