Does Grapefruit Juice Interact with Bexarotene?
Grapefruit Juice and Bexarotene have a moderate drug interaction according to U.S. FDA drug labeling data. Concomitant grapefruit juice could increase bexarotene plasma concentrations through CYP3A4 inhibition, though increases unlikely to cause adverse effects with gel formulations. The mechanism involves inhibition of cytochrome p450 3a4. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Bexarotene Class
- Retinoid
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Grapefruit Juice and Bexarotene occurs because inhibition of cytochrome p450 3a4. Clinically, this means concomitant grapefruit juice could increase bexarotene plasma concentrations through cyp3a4 inhibition, though increases unlikely to cause adverse effects with gel formulations. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Grapefruit Juice and your doctor is considering prescribing Bexarotene (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider