Does Hyaluronidase Interact with Lidocaine With Epinephrine?
Hyaluronidase and Lidocaine With Epinephrine have a moderate drug interaction according to U.S. FDA drug labeling data. 2% lidocaine with 1:100,000 or 1:200,000 epinephrine is incompatible with hyaluronidase due to sodium metabisulfite present in anesthetic formulation. The mechanism involves sodium metabisulfite additive in epinephrine-containing anesthetic products. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Hyaluronidase Class
- Endoglycosidase
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Hyaluronidase and Lidocaine With Epinephrine occurs because sodium metabisulfite additive in epinephrine-containing anesthetic products. Clinically, this means 2% lidocaine with 1:100,000 or 1:200,000 epinephrine is incompatible with hyaluronidase due to sodium metabisulfite present in anesthetic formulation. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Hyaluronidase and your doctor is considering prescribing Lidocaine With Epinephrine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider