Does Ibuprofen Interact with Methotrexate?
CDI records a major classification for Ibuprofen and Methotrexate. The stored summary is: NSAIDs competitively inhibit methotrexate accumulation and may enhance methotrexate toxicity. Caution should be used when administered concomitantly. The mechanism involves competitive inhibition of methotrexate accumulation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Ibuprofen Class
- Nonsteroidal Anti-inflammatory Drug
- Methotrexate Class
- Folate Analog Metabolic Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Competitive inhibition of methotrexate accumulation
What To Tell Your Doctor or Pharmacist
If you are taking Ibuprofen and your doctor is considering prescribing Methotrexate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider