Does Ibuprofen Interact with Ranitidine?
Ibuprofen and Ranitidine have a minor drug interaction according to U.S. FDA drug labeling data. Co-administration of ranitidine with ibuprofen had no substantive effect on ibuprofen serum concentrations in human volunteer studies. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Ibuprofen Class
- Nonsteroidal Anti-inflammatory Drug
- Ranitidine Class
- Histamine-2 Receptor Antagonist
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Ibuprofen and your doctor is considering prescribing Ranitidine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider