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Does Ibuprofen And Famotidine Interact with Selective Serotonin Reuptake Inhibitors Ssri?

CDI records a major classification for Ibuprofen And Famotidine and Selective Serotonin Reuptake Inhibitors Ssri. The stored summary is: SSRIs with ibuprofen potentiate bleeding risk more than NSAID alone due to interference with serotonin reuptake. The mechanism involves interference with serotonin reuptake and platelet hemostasis. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.

Severity: Major
Ibuprofen And Famotidine Class: Histamine-2 Receptor Antagonist
Management: Close medical supervision required
Data Source: U.S. FDA via OpenFDA

Recorded Mechanism

Interference with serotonin reuptake and platelet hemostasis

What To Tell Your Doctor or Pharmacist

If you are taking Ibuprofen And Famotidine and your doctor is considering prescribing Selective Serotonin Reuptake Inhibitors Ssri (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask how frequently you should be monitored while these are co-prescribed
Ask whether any dosage adjustments are needed
Never stop or change either medication without first consulting your healthcare provider

💊 Ibuprofen And Famotidine(Duexis)+💊 Selective Serotonin Reuptake Inhibitors Ssri

Severity & Interaction Details

⚠️

major

Use with caution — major interaction

Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.

Severity scale

MinorContra

On record

Yes

Drug A class

Histamine-2 Receptor Antagonist

Drug B class

—

Source

NLP:ibuprofen and famotidine

What this means in plain English

SSRIs with ibuprofen potentiate bleeding risk more than NSAID alone due to interference with serotonin reuptake.

About Ibuprofen And Famotidine and Selective Serotonin Reuptake Inhibitors Ssri

Ibuprofen And Famotidine is a Histamine-2 Receptor Antagonist. Ibuprofen And Famotidine is also sold under the brand name Duexis. Ibuprofen And Famotidine additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: NLP:ibuprofen and famotidine

Recent research & FDA safety updates

Live

Auto-aggregated from PubMed E-utilities and FDA safety data.

FDA

FDA Safety Alert: Famotidine Injection, USP, 20 mg per 2 mL (10 mg per mL), 2 mL vials, Rx only, Fresenius Kabi USA, Labout Ibuprofen And Famotidine · 2025-12

PubMed

Serotonergic signaling in gastric physiology and motility disorders.about Selective Serotonin Reuptake Inhibitors Ssri · 2026-07

PubMed

Clinical symptoms and cognitive functioning following adjunctive N-acetylcysteine in obsessive-compulsive disorder: a double-blind, placebo-controlled trial.about Selective Serotonin Reuptake Inhibitors Ssri · 2026-06

PubMed

Evaluating Treatment Sequences in Major Depressive Disorder Using an Open-Source Health Economic Model Based on Stakeholder and Patient Engagement.about Selective Serotonin Reuptake Inhibitors Ssri · 2026-06

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How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.