Does Indomethacin Interact with Captopril?
Indomethacin and Captopril have a moderate drug interaction according to U.S. FDA drug labeling data. Indomethacin can reduce the antihypertensive effects of captopril. May result in further deterioration of renal function in patients with compromised renal function. The mechanism involves nsaids may diminish the antihypertensive effect of ace-inhibitors. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Indomethacin Class
- Nonsteroidal Anti-inflammatory Drug
- Captopril Class
- Angiotensin Converting Enzyme Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Indomethacin and Captopril occurs because nsaids may diminish the antihypertensive effect of ace-inhibitors. Clinically, this means indomethacin can reduce the antihypertensive effects of captopril. may result in further deterioration of renal function in patients with compromised renal function. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Indomethacin and your doctor is considering prescribing Captopril (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider