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Does Indomethacin Interact with Diflunisal?

Indomethacin and Diflunisal have a contraindicated drug interaction according to U.S. FDA drug labeling data. Combined use has been associated with fatal gastrointestinal hemorrhage. Diflunisal decreases renal clearance and significantly increases plasma levels of indomethacin. The mechanism involves diflunisal decreases renal clearance of indomethacin. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Indomethacin Class
Nonsteroidal Anti-inflammatory Drug
Diflunisal Class
Nonsteroidal Anti-inflammatory Drug
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Indomethacin and Diflunisal occurs because diflunisal decreases renal clearance of indomethacin. Clinically, this means combined use has been associated with fatal gastrointestinal hemorrhage. diflunisal decreases renal clearance and significantly increases plasma levels of indomethacin. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Indomethacin and your doctor is considering prescribing Diflunisal (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Indomethacin(Indomethacin)+💊 Diflunisal(Diflunisal)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Nonsteroidal Anti-inflammatory Drug
Drug B class
Nonsteroidal Anti-inflammatory Drug
Source
NLP:indomethacin

What this means in plain English

Combined use has been associated with fatal gastrointestinal hemorrhage. Diflunisal decreases renal clearance and significantly increases plasma levels of indomethacin.

What the FDA label says

"Diflunisal decreases renal clearance of indomethacin"

📖 Source: NLP:indomethacin

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.