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Does Indomethacin Interact with Glucagon Injection Solution?

Indomethacin and Glucagon Injection Solution have a major drug interaction according to U.S. FDA drug labeling data. In patients taking indomethacin, glucagon may lose its ability to raise blood glucose or may produce hypoglycemia. Monitor blood glucose levels during glucagon treatment. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Indomethacin Class
Nonsteroidal Anti-inflammatory Drug
Glucagon Injection Solution Class
Antihypoglycemic Agent
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Indomethacin and your doctor is considering prescribing Glucagon Injection Solution (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Indomethacin(Tivorbex)+💊 Glucagon Injection Solution(Gvoke Hypopen 0.5 Mg Auto-Injector)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Nonsteroidal Anti-inflammatory Drug
Drug B class
Antihypoglycemic Agent
Source
NLP:glucagon injection, solution

What this means in plain English

In patients taking indomethacin, glucagon may lose its ability to raise blood glucose or may produce hypoglycemia. Monitor blood glucose levels during glucagon treatment.

About Indomethacin and Glucagon Injection Solution

Indomethacin is a Nonsteroidal Anti-inflammatory Drug, while Glucagon Injection Solution is an Antihypoglycemic Agent. Indomethacin is also sold under the brand name Tivorbex. Indomethacin is taken by mouth, whereas Glucagon Injection Solution is given by injection under the skin. Indomethacin additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.