Does Infliximab Interact with Cyclosporine?
CDI records a moderate classification for Infliximab and Cyclosporine. The stored summary is: Monitoring of drug concentration recommended upon initiation or discontinuation of infliximab; individual dose adjustment may be needed. The mechanism involves cyp450 enzyme normalization by infliximab may affect cyclosporine metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Infliximab Class
- Tumor Necrosis Factor Blocker
- Cyclosporine Class
- Calcineurin Inhibitor Immunosuppressant
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP450 enzyme normalization by infliximab may affect cyclosporine metabolism
What To Tell Your Doctor or Pharmacist
If you are taking Infliximab and your doctor is considering prescribing Cyclosporine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider