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Does Insulin Human Interact with Metoclopramide Hydrochloride?

Insulin Human and Metoclopramide Hydrochloride have a major drug interaction according to U.S. FDA drug labeling data. Metoclopramide may affect insulin absorption and action timing, potentially leading to hypoglycemia; insulin dosage or timing may require adjustment. The mechanism involves altered delivery of food to intestines affecting absorption rate. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Insulin Human Class
Insulin
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Insulin Human and Metoclopramide Hydrochloride occurs because altered delivery of food to intestines affecting absorption rate. Clinically, this means metoclopramide may affect insulin absorption and action timing, potentially leading to hypoglycemia; insulin dosage or timing may require adjustment. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Insulin Human and your doctor is considering prescribing Metoclopramide Hydrochloride (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Insulin Human(Myxredlin)+💊 Metoclopramide Hydrochloride(Metoclopramide)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Insulin
Drug B class
—
Source
NLP:metoclopramide hydrochloride

What this means in plain English

Metoclopramide may affect insulin absorption and action timing, potentially leading to hypoglycemia; insulin dosage or timing may require adjustment.

What the FDA label says

"Altered delivery of food to intestines affecting absorption rate"

📖 Source: NLP:metoclopramide hydrochloride

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.