Metoclopramide Hydrochloride has 29 known drug interactions based on U.S. FDA drug labeling data. Of these, 12 are contraindicated combinations that should be avoided entirely. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alcohol, Apomorphine, Bromocriptine. Patients taking Metoclopramide Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 29
- Contraindicated
- 12
- Major
- 5
- Moderate
- 9
Contraindicated (12)
- Metoclopramide Hydrochloride + Alcohol— CNS depressant; increased risk of CNS depression. Avoid concomitant use.
- Metoclopramide Hydrochloride + Apomorphine— Dopaminergic agonist with opposing effects on dopamine; potential exacerbation of parkinsonian symptoms. Avoid concomita…
- Metoclopramide Hydrochloride + Bromocriptine— Dopaminergic agonist with opposing effects on dopamine; potential exacerbation of symptoms. Avoid concomitant use.
- Metoclopramide Hydrochloride + Cabergoline— Dopaminergic agonist with opposing effects on dopamine; potential exacerbation of symptoms. Avoid concomitant use.
- Metoclopramide Hydrochloride + Cns Depressants— Increased risk of CNS depression; avoid concomitant use and monitor for adverse reactions.
- Metoclopramide Hydrochloride + Levodopa— Dopaminergic agent with opposing effects on dopamine; potential exacerbation of parkinsonian symptoms. Avoid concomitant…
- Metoclopramide Hydrochloride + Mao Inhibitors— Increased risk of hypertension; avoid concomitant use.
- Metoclopramide Hydrochloride + Monoamine Oxidase Inhibitors (Maois)— Increased risk of hypertension. Avoid concomitant use.
- Metoclopramide Hydrochloride + Pramipexole— Dopaminergic agonist with opposing effects on dopamine; potential exacerbation of symptoms. Avoid concomitant use.
- Metoclopramide Hydrochloride + Ropinirole— Dopaminergic agonist with opposing effects on dopamine; potential exacerbation of symptoms. Avoid concomitant use.
- Metoclopramide Hydrochloride + Rotigotine— Dopaminergic agonist with opposing effects on dopamine; potential exacerbation of symptoms. Avoid concomitant use.
- Metoclopramide Hydrochloride + Sedatives— CNS depressants; increased risk of CNS depression. Avoid concomitant use.
Major (5)
- Metoclopramide Hydrochloride + Bupropion— Strong CYP2D6 inhibitor increasing metoclopramide plasma concentrations with risk of exacerbation of extrapyramidal symp…
- Metoclopramide Hydrochloride + Fluoxetine— Strong CYP2D6 inhibitor increasing metoclopramide plasma concentrations with risk of exacerbation of extrapyramidal symp…
- Metoclopramide Hydrochloride + Insulin Human— Metoclopramide may affect insulin absorption and action timing, potentially leading to hypoglycemia; insulin dosage or t…
- Metoclopramide Hydrochloride + Paroxetine— Strong CYP2D6 inhibitor increasing metoclopramide plasma concentrations with risk of exacerbation of extrapyramidal symp…
- Metoclopramide Hydrochloride + Quinidine— Strong CYP2D6 inhibitor increasing metoclopramide plasma concentrations with risk of exacerbation of extrapyramidal symp…
Moderate (9)
- Metoclopramide Hydrochloride + Acetaminophen— Metoclopramide may increase the rate and/or extent of absorption of acetaminophen from the small bowel.
- Metoclopramide Hydrochloride + Antiperistaltic Antidiarrheal Drugs— Potential for decreased metoclopramide effect due to opposing effects on gastrointestinal motility. Monitor for reduced …
- Metoclopramide Hydrochloride + Cyclosporine— Metoclopramide may increase the rate and/or extent of absorption of cyclosporine from the small bowel.
- Metoclopramide Hydrochloride + Digoxin— Metoclopramide may diminish absorption of digoxin from the stomach.
- Metoclopramide Hydrochloride + Fosfomycin— Intervention Drugs with Decreased Absorption (e.g., digoxin, atovaquone, posaconazole oral suspension*, fosfomycin) : Mo…
- Metoclopramide Hydrochloride + Opioid Analgesics— Narcotic analgesics antagonize the effects of metoclopramide on gastrointestinal motility.
- Metoclopramide Hydrochloride + Posaconazole— Intervention Drugs with Decreased Absorption (e.g., digoxin, atovaquone, posaconazole oral suspension*, fosfomycin) : Mo…
- Metoclopramide Hydrochloride + Tetracycline— Metoclopramide may increase the rate and/or extent of absorption of tetracycline from the small bowel.
- Metoclopramide Hydrochloride + Tranquilizers— Additive sedative effects can occur when metoclopramide is given with tranquilizers.