Does Irinotecan Hydrochloride Interact with Gemfibrozil?
CDI records a contraindicated classification for Irinotecan Hydrochloride and Gemfibrozil. The stored summary is: UGT1A1 inhibitor may increase systemic exposure to irinotecan or SN-38. Do not administer unless no therapeutic alternatives. The mechanism involves ugt1a1 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Gemfibrozil Class
- Peroxisome Proliferator Receptor alpha Agonist
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
UGT1A1 inhibition
What To Tell Your Doctor or Pharmacist
If you are taking Irinotecan Hydrochloride and your doctor is considering prescribing Gemfibrozil (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider