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Does Itraconazole Interact with Montelukast Sodium?

Itraconazole and Montelukast Sodium have a minor drug interaction according to U.S. FDA drug labeling data. No dose adjustment needed when co-administered with montelukast sodium. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Itraconazole Class
Azole Antifungal
Montelukast Sodium Class
Leukotriene Receptor Antagonist
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Itraconazole and your doctor is considering prescribing Montelukast Sodium (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Itraconazole(Sporanox)+💊 Montelukast Sodium(Montelukast Sodium)

Severity & Interaction Details

✅
minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
Azole Antifungal
Drug B class
Leukotriene Receptor Antagonist
Source
NLP:montelukast sodium

What this means in plain English

No dose adjustment needed when co-administered with montelukast sodium.

About Itraconazole and Montelukast Sodium

Itraconazole is an Azole Antifungal, while Montelukast Sodium is a Leukotriene Receptor Antagonist. Itraconazole is also sold under the brand name Sporanox. Both medications are taken by mouth. Both Itraconazole and Montelukast Sodium carry an FDA boxed warning — the agency's most serious safety designation.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.