Does Ketorolac Tromethamine Interact with Probenecid?
CDI records a major classification for Ketorolac Tromethamine and Probenecid. The stored summary is: Probenecid significantly decreases ketorolac clearance and volume of distribution, increasing total AUC approximately threefold and terminal half-life approximately twofold. The mechanism involves decreased clearance and volume of distribution of ketorolac. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Decreased clearance and volume of distribution of ketorolac
What To Tell Your Doctor or Pharmacist
If you are taking Ketorolac Tromethamine and your doctor is considering prescribing Probenecid (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider