Home›Ketorolac Tromethamine›Ketorolac Tromethamine + Probenecid

Does Ketorolac Tromethamine Interact with Probenecid?

Ketorolac Tromethamine and Probenecid have a major drug interaction according to U.S. FDA drug labeling data. Probenecid significantly decreases ketorolac clearance and volume of distribution, increasing total AUC approximately threefold and terminal half-life approximately twofold. The mechanism involves decreased clearance and volume of distribution of ketorolac. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Ketorolac Tromethamine and Probenecid occurs because decreased clearance and volume of distribution of ketorolac. Clinically, this means probenecid significantly decreases ketorolac clearance and volume of distribution, increasing total auc approximately threefold and terminal half-life approximately twofold. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Ketorolac Tromethamine and your doctor is considering prescribing Probenecid (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Ketorolac Tromethamine(Ketorolac Tromethamine)+💊 Probenecid(Probenecid)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:ketorolac tromethamine

What this means in plain English

Probenecid significantly decreases ketorolac clearance and volume of distribution, increasing total AUC approximately threefold and terminal half-life approximately twofold.

What the FDA label says

"Decreased clearance and volume of distribution of ketorolac"

📖 Source: NLP:ketorolac tromethamine

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.