Does Labetalol Hydrochloride Interact with Cimetidine?
CDI records a moderate classification for Labetalol Hydrochloride and Cimetidine. The stored summary is: Cimetidine increases bioavailability of labetalol; special care needed in establishing required dose for blood pressure control. The mechanism involves enhanced absorption or altered hepatic metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Labetalol Hydrochloride Class
- beta-Adrenergic Blocker
- Cimetidine Class
- Histamine-2 Receptor Antagonist
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Enhanced absorption or altered hepatic metabolism
What To Tell Your Doctor or Pharmacist
If you are taking Labetalol Hydrochloride and your doctor is considering prescribing Cimetidine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider