Does Labetalol Hydrochloride Interact with Diltiazem?
CDI records a major classification for Labetalol Hydrochloride and Diltiazem. The stored summary is: Concomitant use can increase risk of bradycardia or hypotension due to slowed atrioventricular conduction and decreased heart rate. The mechanism involves both are negative chronotropes that slow atrioventricular conduction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Labetalol Hydrochloride Class
- beta-Adrenergic Blocker
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Both are negative chronotropes that slow atrioventricular conduction
What To Tell Your Doctor or Pharmacist
If you are taking Labetalol Hydrochloride and your doctor is considering prescribing Diltiazem (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider