Does Lacosamide Interact with Omeprazole?
Lacosamide and Omeprazole have a minor drug interaction according to U.S. FDA drug labeling data. In vivo study with omeprazole did not show an inhibitory effect on omeprazole pharmacokinetics despite in vitro potential to inhibit CYP2C19. The mechanism involves no clinically significant cyp2c19 inhibition in vivo. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Omeprazole Class
- Proton Pump Inhibitor
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Lacosamide and Omeprazole occurs because no clinically significant cyp2c19 inhibition in vivo. Clinically, this means in vivo study with omeprazole did not show an inhibitory effect on omeprazole pharmacokinetics despite in vitro potential to inhibit cyp2c19. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Lacosamide and your doctor is considering prescribing Omeprazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider