Does Lamivudine And Tenofovir Disoproxil Fumarate Interact with Lopinavir And Ritonavir?
CDI records a major classification for Lamivudine And Tenofovir Disoproxil Fumarate and Lopinavir And Ritonavir. The stored summary is: Increases tenofovir concentrations. Monitor for tenofovir-associated adverse reactions; discontinue if adverse reactions develop. The mechanism involves increases tenofovir concentrations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Lamivudine And Tenofovir Disoproxil Fumarate Class
- Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
- Lopinavir And Ritonavir Class
- Protease Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increases tenofovir concentrations
What To Tell Your Doctor or Pharmacist
If you are taking Lamivudine And Tenofovir Disoproxil Fumarate and your doctor is considering prescribing Lopinavir And Ritonavir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider