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Does Lamotrigine Extended Release Interact with Dofetilide?

Lamotrigine Extended Release and Dofetilide have a contraindicated drug interaction according to U.S. FDA drug labeling data. Coadministration with lamotrigine ER is not recommended due to narrow therapeutic index and increased plasma levels via OCT2 inhibition. The mechanism involves inhibition of organic cationic transporter 2 (oct2)-mediated renal tubular secretion. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Lamotrigine Extended Release Class
Anti-epileptic Agent
Dofetilide Class
Antiarrhythmic
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Lamotrigine Extended Release and Dofetilide occurs because inhibition of organic cationic transporter 2 (oct2)-mediated renal tubular secretion. Clinically, this means coadministration with lamotrigine er is not recommended due to narrow therapeutic index and increased plasma levels via oct2 inhibition. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Lamotrigine Extended Release and your doctor is considering prescribing Dofetilide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Lamotrigine Extended Release(Lamotrigine)+💊 Dofetilide(Dofetilide)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Anti-epileptic Agent
Drug B class
Antiarrhythmic
Source
NLP:lamotrigine er

What this means in plain English

Coadministration with lamotrigine ER is not recommended due to narrow therapeutic index and increased plasma levels via OCT2 inhibition.

What the FDA label says

"Inhibition of organic cationic transporter 2 (OCT2)-mediated renal tubular secretion"

📖 Source: NLP:lamotrigine er

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.