Does Lansoprazole Amoxicillin Clarithromycin Interact with Omeprazole?
Lansoprazole Amoxicillin Clarithromycin and Omeprazole have a moderate drug interaction according to U.S. FDA drug labeling data. Proton Pump Inhibitors: Omeprazole No Dose Adjustment Omeprazole : The mean 24 hour gastric pH value was 5.2 when omeprazole was administered alone and 5.7 when coadministered with clarithromycin as a result of increased omeprazole exposures (see also Omeprazole under "Drugs That Affect Clarithromycin Tablets" in the table below). Saquinavir (in patients with normal renal function) Ritonavir (in patients with normal renal function) No Dose Adjustment Proton Pump Inhibitors: Omeprazole Use With Caution Omeprazole : Clarithromycin concentrations in the gastric tissue and mucus were also increased by concomitant administration of omeprazole. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Omeprazole Class
- Proton Pump Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Lansoprazole Amoxicillin Clarithromycin and your doctor is considering prescribing Omeprazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider