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Does Ledipasvir Interact with Ibuprofen And Famotidine?

Ledipasvir and Ibuprofen And Famotidine have a unknown drug interaction according to U.S. FDA drug labeling data. For administration instructions of other drugs whose absorption is dependent on gastric pH, refer to their prescribing information (e.g., atazanavir, erlotinib, ketoconazole, itraconazole, nilotinib, ledipasvir/sofosbuvir, and rilpivirine). Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity: Unknown
Ibuprofen And Famotidine Class: Histamine-2 Receptor Antagonist
Management: Consult your pharmacist
Data Source: U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Ledipasvir and your doctor is considering prescribing Ibuprofen And Famotidine (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Never stop or change either medication without first consulting your healthcare provider

💊 Ledipasvir+💊 Ibuprofen And Famotidine(Ibuprofen And Famotidine)

Severity & Interaction Details

ℹ️

unknown

Interaction documented — severity unclassified

The FDA label notes an interaction but the severity is not classified in our dataset.

Severity scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

Histamine-2 Receptor Antagonist

Source

FDA drug label - ibuprofen and famotidine

What this means in plain English

For administration instructions of other drugs whose absorption is dependent on gastric pH, refer to their prescribing information (e.g., atazanavir, erlotinib, ketoconazole, itraconazole, nilotinib, ledipasvir/sofosbuvir, and rilpivirine).

Recent research & FDA safety updates

Live

Auto-aggregated from PubMed E-utilities and FDA safety data.

FDA

FDA Safety Alert: Famotidine Injection, USP, 20 mg per 2 mL (10 mg per mL), 2 mL vials, Rx only, Fresenius Kabi USA, Labout Ibuprofen And Famotidine · 2025-12

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Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.