Home›Ledipasvir And Sofosbuvir›Ledipasvir And Sofosbuvir + Rosuvastatin

Does Ledipasvir And Sofosbuvir Interact with Rosuvastatin?

Ledipasvir And Sofosbuvir and Rosuvastatin have a contraindicated drug interaction according to U.S. FDA drug labeling data. Combination may significantly increase rosuvastatin exposure. Concomitant use with rosuvastatin is not recommended. The mechanism involves increased rosuvastatin exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Ledipasvir And Sofosbuvir Class
Hepatitis C Virus NS5A Inhibitor
Rosuvastatin Class
HMG-CoA Reductase Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Ledipasvir And Sofosbuvir and Rosuvastatin occurs because increased rosuvastatin exposure. Clinically, this means combination may significantly increase rosuvastatin exposure. concomitant use with rosuvastatin is not recommended. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Ledipasvir And Sofosbuvir and your doctor is considering prescribing Rosuvastatin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Ledipasvir And Sofosbuvir(Ledipasvir And Sofosbuvir)+💊 Rosuvastatin

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Hepatitis C Virus NS5A Inhibitor
Drug B class
HMG-CoA Reductase Inhibitor
Source
NLP:rosuvastatin

What this means in plain English

Combination may significantly increase rosuvastatin exposure. Concomitant use with rosuvastatin is not recommended.

What the FDA label says

"Increased rosuvastatin exposure"

📖 Source: NLP:rosuvastatin

Share this result:

WhatsAppText / SMSEmail
Also share on:XFacebook
Add more drugs
Check Ledipasvir And Sofosbuvir and Rosuvastatin against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.