Does Leflunomide Interact with Pioglitazone?
CDI records a moderate classification for Leflunomide and Pioglitazone. The stored summary is: Exposure to pioglitazone may be increased when coadministered with leflunomide. Monitor and adjust dose as required. The mechanism involves teriflunomide inhibits cyp2c8, which metabolizes pioglitazone. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Leflunomide Class
- Antirheumatic Agent
- Pioglitazone Class
- Peroxisome Proliferator Receptor alpha Agonist
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Teriflunomide inhibits CYP2C8, which metabolizes pioglitazone
What To Tell Your Doctor or Pharmacist
If you are taking Leflunomide and your doctor is considering prescribing Pioglitazone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider