Does Levonordefrin Interact with Mepivacaine Hydrochloride?
CDI records a major classification for Levonordefrin and Mepivacaine Hydrochloride. The stored summary is: Local anesthetic solutions containing Levonordefrin may produce severe, prolonged hypertension in patients receiving tricyclic antidepressants or monoamine oxidase inhibitors. The mechanism involves vasopressor effect potentiation with monoamine oxidase inhibitors and tricyclic antidepressants. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Vasopressor effect potentiation with monoamine oxidase inhibitors and tricyclic antidepressants
What To Tell Your Doctor or Pharmacist
If you are taking Levonordefrin and your doctor is considering prescribing Mepivacaine Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider