Does Levothyroxine Interact with Semaglutide?
CDI records a moderate classification for Levothyroxine and Semaglutide. The stored summary is: Semaglutide tablet increased levothyroxine exposure by 33%. Monitor effects and consider increased clinical monitoring with concomitant use. The mechanism involves delayed gastric emptying increases absorption of levothyroxine. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Semaglutide Class
- GLP-1 Receptor Agonist
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Delayed gastric emptying increases absorption of levothyroxine
What To Tell Your Doctor or Pharmacist
If you are taking Levothyroxine and your doctor is considering prescribing Semaglutide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider