Does Lidocaine Menthol Interact with Mexiletine?
CDI records a major classification for Lidocaine Menthol and Mexiletine. The stored summary is: Concurrent use may result in additive and potentially synergistic toxic effects due to both being Class I antiarrhythmic drugs. The mechanism involves additive and potentially synergistic toxic effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Lidocaine Menthol Class
- Amide Local Anesthetic
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Additive and potentially synergistic toxic effects
What To Tell Your Doctor or Pharmacist
If you are taking Lidocaine Menthol and your doctor is considering prescribing Mexiletine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider