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Mexiletine

25 interactions on record

Mexiletine has 25 known drug interactions based on U.S. FDA drug labeling data. 13 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Lidocaine, Lidocaine 5%, Lidocaine And Prilocaine. Patients taking Mexiletine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 25
Major: 13
Moderate: 12

Major (13)

Mexiletine + Lidocaine— Class I antiarrhythmic; toxic effects are additive and potentially synergistic when used with lidocaine patch 5%.
Mexiletine + Lidocaine 5%— Class I antiarrhythmic; toxic effects are additive and potentially synergistic with lidocaine patch 5%.
Mexiletine + Lidocaine And Prilocaine— Class I antiarrhythmic; toxic effects are additive and potentially synergistic when used with lidocaine and prilocaine c…
Mexiletine + Lidocaine Hydrochloride— Additive and potentially synergistic toxic effects when used concomitantly with lidocaine hydrochloride. Use with cautio…
Mexiletine + Lidocaine Hydrochloride, Menthol— Additive and potentially synergistic toxic effects when used concomitantly with lidocaine hydrochloride and menthol spra…
Mexiletine + Lidocaine, Dimethicone— Lidocaine patch 5% with mexiletine has additive and potentially synergistic toxic effects. Use with caution in patients …
Mexiletine + Lidocaine, Isopropyl Alcohol— Additive and potentially synergistic toxic effects when used concomitantly with lidocaine.
Mexiletine + Lidocaine, Menthol— Concurrent use may result in additive and potentially synergistic toxic effects due to both being Class I antiarrhythmic…
Mexiletine + Tizanidine— CYP1A2 inhibitor antiarrhythmic; concomitant use should be avoided due to potential for hypotension, bradycardia, or exc…
Mexiletine + Tizanidine Hydrochloride— Concomitant use should be avoided due to potential interactions. If clinically necessary, initiate with 2 mg and titrate…
Mexiletine + Tizanidne Hydrochloride— Should be avoided due to CYP1A2 inhibition. If necessary, initiate tizanidine at 2 mg and titrate cautiously; monitor fo…
Mexiletine + Warfarin— CYP1A2 inhibitor that increases warfarin effect and INR; requires close INR monitoring
Mexiletine + Warfarin Sodium— CYP1A2 inhibitor that increases warfarin effect and INR; requires closer INR monitoring.

Moderate (12)

Mexiletine + Atropine Sulfate— Atropine Sulfate decreases the rate of mexiletine absorption without altering relative oral bioavailability. This delay …
Mexiletine + Atropine Sulfate Injection— Atropine Sulfate Injection decreased the rate of mexiletine absorption without altering relative oral bioavailability. T…
Mexiletine + Lidocaine And Capsaicin— Class I antiarrhythmic drug; toxic effects are additive and potentially synergistic when used with lidocaine and capsaic…
Mexiletine + Lidocaine And Tetracaine— Class I antiarrhythmic drug with additive and potentially synergistic systemic toxic effects when used with lidocaine an…
Mexiletine + Lidocaine Hcl, Benzalkonium Chloride— Additive and potentially synergistic toxic effects when used concomitantly with lidocaine HCl/benzalkonium chloride. Use…
Mexiletine + Lidocaine Patch 5%— Toxic effects are additive and potentially synergistic; use with caution in patients receiving Class I antiarrhythmic dr…
Mexiletine + Lidothol Es Patch— Use with caution due to additive and potentially synergistic toxic effects when combined with lidocaine.
Mexiletine + Quinidine Gluconate— Quinidine may affect mexiletine metabolism via cytochrome P450 IID6 inhibition; monitoring recommended.
Mexiletine + Quinidine Sulfate Tablet— Quinidine inhibits P450 IID6-dependent metabolism, potentially increasing mexiletine levels.
Mexiletine + Rifapentine— Rifapentine may increase metabolism and decrease activity. Dosage adjustment may be necessary.
Mexiletine + Riluzole— CYP1A2 inhibitor that may increase riluzole exposure and risk of riluzole-associated adverse reactions.
Mexiletine + Trubrexa Patch Er— Toxic effects are additive and potentially synergistic when used concomitantly with Trubrexa Transdermal Patch; use with…

Mexiletine + Lidocaine⚠️Major

Class I antiarrhythmic; toxic effects are additive and potentially synergistic when used with lidocaine patch 5%.

Mexiletine + Lidocaine 5%⚠️Major

Class I antiarrhythmic; toxic effects are additive and potentially synergistic with lidocaine patch 5%.

Mexiletine + Lidocaine And Prilocaine⚠️Major

Class I antiarrhythmic; toxic effects are additive and potentially synergistic when used with lidocaine and prilocaine cream.

Mexiletine + Lidocaine Hydrochloride⚠️Major

Additive and potentially synergistic toxic effects when used concomitantly with lidocaine hydrochloride. Use with caution.

Mexiletine + Lidocaine Hydrochloride, Menthol⚠️Major

Additive and potentially synergistic toxic effects when used concomitantly with lidocaine hydrochloride and menthol spray.

Mexiletine + Lidocaine, Dimethicone⚠️Major

Lidocaine patch 5% with mexiletine has additive and potentially synergistic toxic effects. Use with caution in patients receiving Class I antiarrhythmic drugs.

Mexiletine + Lidocaine, Isopropyl Alcohol⚠️Major

Additive and potentially synergistic toxic effects when used concomitantly with lidocaine.

Mexiletine + Lidocaine, Menthol⚠️Major

Concurrent use may result in additive and potentially synergistic toxic effects due to both being Class I antiarrhythmic drugs.

Mexiletine + Tizanidine⚠️Major

CYP1A2 inhibitor antiarrhythmic; concomitant use should be avoided due to potential for hypotension, bradycardia, or excessive drowsiness.

Mexiletine + Tizanidine Hydrochloride⚠️Major

Concomitant use should be avoided due to potential interactions. If clinically necessary, initiate with 2 mg and titrate cautiously.

Mexiletine + Tizanidne Hydrochloride⚠️Major

Should be avoided due to CYP1A2 inhibition. If necessary, initiate tizanidine at 2 mg and titrate cautiously; monitor for hypotension, bradycardia, or excessive drowsiness.

Mexiletine + Warfarin⚠️Major

CYP1A2 inhibitor that increases warfarin effect and INR; requires close INR monitoring

Mexiletine + Warfarin Sodium⚠️Major

CYP1A2 inhibitor that increases warfarin effect and INR; requires closer INR monitoring.

Mexiletine + Atropine Sulfate🟡Moderate

Atropine Sulfate decreases the rate of mexiletine absorption without altering relative oral bioavailability. This delay can be reversed by combining atropine with intravenous metoclopramide.

Mexiletine + Atropine Sulfate Injection🟡Moderate

Atropine Sulfate Injection decreased the rate of mexiletine absorption without altering relative oral bioavailability. This delay was reversed by combination of atropine and intravenous metoclopramide.

Mexiletine + Lidocaine And Capsaicin🟡Moderate

Class I antiarrhythmic drug; toxic effects are additive and potentially synergistic when used with lidocaine and capsaicin patch.

Mexiletine + Lidocaine And Tetracaine🟡Moderate

Class I antiarrhythmic drug with additive and potentially synergistic systemic toxic effects when used with lidocaine and tetracaine. Use with caution.

Mexiletine + Lidocaine Hcl, Benzalkonium Chloride🟡Moderate

Additive and potentially synergistic toxic effects when used concomitantly with lidocaine HCl/benzalkonium chloride. Use with caution.

Mexiletine + Lidocaine Patch 5%🟡Moderate

Toxic effects are additive and potentially synergistic; use with caution in patients receiving Class I antiarrhythmic drugs.

Mexiletine + Lidothol Es Patch🟡Moderate

Use with caution due to additive and potentially synergistic toxic effects when combined with lidocaine.

Mexiletine + Quinidine Gluconate🟡Moderate

Quinidine may affect mexiletine metabolism via cytochrome P450 IID6 inhibition; monitoring recommended.

Mexiletine + Quinidine Sulfate Tablet🟡Moderate

Quinidine inhibits P450 IID6-dependent metabolism, potentially increasing mexiletine levels.

Mexiletine + Rifapentine🟡Moderate

Rifapentine may increase metabolism and decrease activity. Dosage adjustment may be necessary.

Mexiletine + Riluzole🟡Moderate

CYP1A2 inhibitor that may increase riluzole exposure and risk of riluzole-associated adverse reactions.

Mexiletine + Trubrexa Patch Er🟡Moderate

Toxic effects are additive and potentially synergistic when used concomitantly with Trubrexa Transdermal Patch; use with caution.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.