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Does Linezolid Interact with Nalbuphine Hydrochloride?

Linezolid and Nalbuphine Hydrochloride have a contraindicated drug interaction according to U.S. FDA drug labeling data. MAOI not recommended; use contraindicated within 14 days of stopping. Can manifest as serotonin syndrome or opioid toxicity. The mechanism involves maoi interaction causing serotonin syndrome and opioid toxicity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Linezolid Class
Oxazolidinone Antibacterial
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Linezolid and Nalbuphine Hydrochloride occurs because maoi interaction causing serotonin syndrome and opioid toxicity. Clinically, this means maoi not recommended; use contraindicated within 14 days of stopping. can manifest as serotonin syndrome or opioid toxicity. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Linezolid and your doctor is considering prescribing Nalbuphine Hydrochloride (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Linezolid(Zyvox)+💊 Nalbuphine Hydrochloride(Nalbuphine Hydrochloride)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Oxazolidinone Antibacterial
Drug B class
—
Source
NLP:nalbuphine hydrochloride

What this means in plain English

MAOI not recommended; use contraindicated within 14 days of stopping. Can manifest as serotonin syndrome or opioid toxicity.

About Linezolid and Nalbuphine Hydrochloride

Linezolid is an Oxazolidinone Antibacterial. Linezolid is also sold under the brand name Zyvox. Linezolid is taken by mouth, whereas Nalbuphine Hydrochloride is given by intramuscular injection. Nalbuphine Hydrochloride additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"MAOI interaction causing serotonin syndrome and opioid toxicity"

📖 Source: NLP:nalbuphine hydrochloride

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.