Does Lithium Interact with Empagliflozin Metformin Hydrochloride?
Lithium and Empagliflozin Metformin Hydrochloride have a moderate drug interaction according to U.S. FDA drug labeling data. SGLT2 inhibitor concomitant use with lithium may decrease lithium clearance. The mechanism involves reduced lithium renal elimination. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Empagliflozin Metformin Hydrochloride Class
- Sodium-Glucose Cotransporter 2 Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Lithium and Empagliflozin Metformin Hydrochloride occurs because reduced lithium renal elimination. Clinically, this means sglt2 inhibitor concomitant use with lithium may decrease lithium clearance. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Lithium and your doctor is considering prescribing Empagliflozin Metformin Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider