Does Live Attenuated Vaccines Interact with Peramivir?
Live Attenuated Vaccines and Peramivir have a moderate drug interaction according to U.S. FDA drug labeling data. Antiviral drugs may inhibit viral replication and reduce vaccine efficacy. Avoid use of LAIV within 2 weeks before or 48 hours after RAPIVAB administration unless medically indicated. The mechanism involves potential inhibition of viral replication by antiviral drug reducing vaccine efficacy. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Peramivir Class
- Neuraminidase Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Live Attenuated Vaccines and Peramivir occurs because potential inhibition of viral replication by antiviral drug reducing vaccine efficacy. Clinically, this means antiviral drugs may inhibit viral replication and reduce vaccine efficacy. avoid use of laiv within 2 weeks before or 48 hours after rapivab administration unless medically indicated. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Live Attenuated Vaccines and your doctor is considering prescribing Peramivir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider