Does Lonapegsomatropin Tcgd Interact with Cortisone Acetate?
Lonapegsomatropin Tcgd and Cortisone Acetate have a moderate drug interaction according to U.S. FDA drug labeling data. SKYTROFA inhibits 11βHSD-1, reducing conversion of cortisone to active cortisol. Patients on glucocorticoid replacement may require increased maintenance or stress doses. The mechanism involves inhibition of microsomal enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βhsd-1). Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Lonapegsomatropin Tcgd Class
- Recombinant Human Growth Hormone
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Lonapegsomatropin Tcgd and Cortisone Acetate occurs because inhibition of microsomal enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βhsd-1). Clinically, this means skytrofa inhibits 11βhsd-1, reducing conversion of cortisone to active cortisol. patients on glucocorticoid replacement may require increased maintenance or stress doses. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Lonapegsomatropin Tcgd and your doctor is considering prescribing Cortisone Acetate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider