Does Lonapegsomatropin Tcgd Interact with Prednisone?
CDI records a moderate classification for Lonapegsomatropin Tcgd and Prednisone. The stored summary is: SKYTROFA inhibits 11βHSD-1, reducing conversion of prednisone to active metabolites. Patients on glucocorticoid replacement may require increased maintenance or stress doses. The mechanism involves inhibition of microsomal enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βhsd-1). Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Lonapegsomatropin Tcgd Class
- Recombinant Human Growth Hormone
- Prednisone Class
- Corticosteroid
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of microsomal enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD-1)
What To Tell Your Doctor or Pharmacist
If you are taking Lonapegsomatropin Tcgd and your doctor is considering prescribing Prednisone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider