Does Lopinavir And Ritonavir Interact with Efavirenz?
Lopinavir And Ritonavir and Efavirenz have a moderate drug interaction according to U.S. FDA drug labeling data. Efavirenz decreases lopinavir concentrations. Once daily dosing not recommended when coadministered. The mechanism involves cyp3a and cyp2b6 induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Lopinavir And Ritonavir Class
- Protease Inhibitor
- Efavirenz Class
- Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Lopinavir And Ritonavir and Efavirenz occurs because cyp3a and cyp2b6 induction. Clinically, this means efavirenz decreases lopinavir concentrations. once daily dosing not recommended when coadministered. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Lopinavir And Ritonavir and your doctor is considering prescribing Efavirenz (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider