Does Losartan Potassium And Hydrochlorothiazide Interact with Erythromycin?
Losartan Potassium And Hydrochlorothiazide and Erythromycin have a minor drug interaction according to U.S. FDA drug labeling data. Erythromycin increased losartan AUC by 30% but had no clinically significant effect on active metabolite. No significant interaction. The mechanism involves cyp450 3a4 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Losartan Potassium And Hydrochlorothiazide Class
- Thiazide Diuretic
- Erythromycin Class
- Macrolide
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Losartan Potassium And Hydrochlorothiazide and Erythromycin occurs because cyp450 3a4 inhibition. Clinically, this means erythromycin increased losartan auc by 30% but had no clinically significant effect on active metabolite. no significant interaction. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Losartan Potassium And Hydrochlorothiazide and your doctor is considering prescribing Erythromycin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider