Does Losartan Potassium And Hydrochlorothiazide Interact with Ketoconazole?
Losartan Potassium And Hydrochlorothiazide and Ketoconazole have a minor drug interaction according to U.S. FDA drug labeling data. Ketoconazole did not affect conversion of losartan to active metabolite after intravenous administration. No clinically significant interaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Losartan Potassium And Hydrochlorothiazide Class
- Thiazide Diuretic
- Ketoconazole Class
- Azole Antifungal
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Losartan Potassium And Hydrochlorothiazide and your doctor is considering prescribing Ketoconazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider