Does Losartan Potassium And Hydrochlorothiazide Interact with Phenobarbital?
Losartan Potassium And Hydrochlorothiazide and Phenobarbital have a moderate drug interaction according to U.S. FDA drug labeling data. Coadministration led to a reduction of about 20% in the AUC of losartan and its active metabolite. Monitor blood pressure control. The mechanism involves cyp450 induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Losartan Potassium And Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Losartan Potassium And Hydrochlorothiazide and Phenobarbital occurs because cyp450 induction. Clinically, this means coadministration led to a reduction of about 20% in the auc of losartan and its active metabolite. monitor blood pressure control. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Losartan Potassium And Hydrochlorothiazide and your doctor is considering prescribing Phenobarbital (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider