Macitentan + Ketoconazole Interaction
Majorinteraction on record
Description
• Strong CYP3A4 inhibitors (ketoconazole, ritonavir) increase exposure to macitentan: avoid co-administration with macitentan ( 7.2 , 12.3 ). 7.2 Strong CYP3A4 Inhibitors Concomitant use of strong CYP3A4 inhibitors like ketoconazole approximately double macitentan exposure.
Source: FDA drug label - macitentan