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Does Magnesium Trisilicate Interact with Nitrofurantoin Monohydratemacrocrystals?

Magnesium Trisilicate and Nitrofurantoin Monohydratemacrocrystals have a moderate drug interaction according to U.S. FDA drug labeling data. Reduces both the rate and extent of nitrofurantoin absorption through adsorption onto magnesium trisilicate surface. The mechanism involves adsorption of nitrofurantoin onto magnesium trisilicate surface. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Nitrofurantoin Monohydratemacrocrystals Class
Nitrofuran Antibacterial
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Magnesium Trisilicate and Nitrofurantoin Monohydratemacrocrystals occurs because adsorption of nitrofurantoin onto magnesium trisilicate surface. Clinically, this means reduces both the rate and extent of nitrofurantoin absorption through adsorption onto magnesium trisilicate surface. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Magnesium Trisilicate and your doctor is considering prescribing Nitrofurantoin Monohydratemacrocrystals (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Magnesium Trisilicate+💊 Nitrofurantoin Monohydratemacrocrystals(Nitrofurantoin (Monohydrate/Macrocrystals))

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Nitrofuran Antibacterial
Source
NLP:nitrofurantoin (monohydrate/macrocrystals)

What this means in plain English

Reduces both the rate and extent of nitrofurantoin absorption through adsorption onto magnesium trisilicate surface.

What the FDA label says

"Adsorption of nitrofurantoin onto magnesium trisilicate surface"

📖 Source: NLP:nitrofurantoin (monohydrate/macrocrystals)

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.